The Benefits Of Serine
Serine is a nonessential amino acid that is essential for the metabolism of fats as well as fatty acids.
Amino acids are the principal building blocks of proteins and
enzymes. They are incorporated into proteins by transfer RNA according
to the genetic code while messenger RNA is being decoded by ribosomes.
During and after the final assembly of a protein, the amino acid
content dictates the spatial and biochemical properties of the protein
or enzyme.
Serine plays a major role in a variety of biosynthetic pathways
including those involving pyrimadines, purines, creatine, and
porphyrins. Serine is also found at the active site in an important
class of enzymes termed "serine proteases" that include trypsin and
chymotrypsin. These enzymes catalyze the hydrolysis of peptide bonds in
polypeptides and proteins, a major function in the digestive process.
Serine is an important precursor of tryptophan and serotonin.
Previous studies of patients with chronic fatigue syndrome (CFS)
demonstrated that serine (CFSUM2) was an important urinary metabolite
discriminating between CFS from control subjects, and was negatively
correlated with CFS neurological symptom index and total symptom index.
Serine synthesis requires both alanine and glycine as precursors, and
also as a result of microbial metabolism.
These studies showed that the low urinary excretion of serine in CFS
patients reported in previous study was associated with a disturbed
gastrointestinal microbial flora. Alteration in the aerobic microbial
flora, particularly the Gram negative enteric organisms, may change the
exogenous supply of serine and contribute to the increased symptoms
expression of patients with CFS.
Chronic fatigue syndrome (CFS) is a disorder which presents with the
characteristic symptom of an extreme sense of fatigue that is
exacerbated by low levels of activity. Studies to date have largely
focused on the skeletal muscle in an attempt to find an explanation for
the symptom of fatigue. The failure of these studies to demonstrate any
consistent abnormalities of the musculature has led to the hypothesis
that the fatigue of CFS may represent a perception of increase effort
associated with muscular work rather than an inability to perform the
required work.
Urinary serine levels were checked and found to be low in 7 patients
whose illness fitted the CDC criteria for a diagnosis of Chronic
Fatigue Syndrome. A low serine level has previously been identified as
a possible urinary marker (previously known as CFSUM2) for CFS. Serine
was prescribed in a dose of 500mg twice daily to these people.
Serine is a nonessential amino acid that is essential for the metabolism of fats as well as fatty acids.
Amino acids are the principal building blocks of proteins and
enzymes. They are incorporated into proteins by transfer RNA according
to the genetic code while messenger RNA is being decoded by ribosomes.
During and after the final assembly of a protein, the amino acid
content dictates the spatial and biochemical properties of the protein
or enzyme.
Serine plays a major role in a variety of biosynthetic pathways
including those involving pyrimadines, purines, creatine, and
porphyrins. Serine is also found at the active site in an important
class of enzymes termed "serine proteases" that include trypsin and
chymotrypsin. These enzymes catalyze the hydrolysis of peptide bonds in
polypeptides and proteins, a major function in the digestive process.
Serine is an important precursor of tryptophan and serotonin.
Previous studies of patients with chronic fatigue syndrome (CFS)
demonstrated that serine (CFSUM2) was an important urinary metabolite
discriminating between CFS from control subjects, and was negatively
correlated with CFS neurological symptom index and total symptom index.
Serine synthesis requires both alanine and glycine as precursors, and
also as a result of microbial metabolism.
These studies showed that the low urinary excretion of serine in CFS
patients reported in previous study was associated with a disturbed
gastrointestinal microbial flora. Alteration in the aerobic microbial
flora, particularly the Gram negative enteric organisms, may change the
exogenous supply of serine and contribute to the increased symptoms
expression of patients with CFS.
Chronic fatigue syndrome (CFS) is a disorder which presents with the
characteristic symptom of an extreme sense of fatigue that is
exacerbated by low levels of activity. Studies to date have largely
focused on the skeletal muscle in an attempt to find an explanation for
the symptom of fatigue. The failure of these studies to demonstrate any
consistent abnormalities of the musculature has led to the hypothesis
that the fatigue of CFS may represent a perception of increase effort
associated with muscular work rather than an inability to perform the
required work.
Urinary serine levels were checked and found to be low in 7 patients
whose illness fitted the CDC criteria for a diagnosis of Chronic
Fatigue Syndrome. A low serine level has previously been identified as
a possible urinary marker (previously known as CFSUM2) for CFS. Serine
was prescribed in a dose of 500mg twice daily to these people.
- HL Butt, RH Dunstan, NR McGregor, TK Roberts, TL Harrison, JR
Grainger. Low Urinary Serine Output is Associated with an Altered
Faecal Microbial Flora in Chronic Fatigue/Pain Patients. 1998 Sydney
ME/CFS Conference - Rosamund Vallings MB BS. THE USE OF SERINE IN THE MANAGEMENT OF CHRONIC FATIGUE SYNDROME 1998 Sydney ME/CFS Conference
- McGregor N.R, et al: Preliminary determination of a molecuar basis
to chronic fatigue syndrome. Biochemical and Molecular Medicine, 1996,
57, 73-80
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