Alzheimer's Disease Genetics
Alzheimer's disease is a common disorder affecting the central Nervous system and the brain, and has been found to be a common cause of dementia.
The basic mechanism in this disease is the formation of plaques on the brain. The amyloid cells are broken down by the enzyme beta-secretase in to smaller cells. These smaller cells then keep on accumulating and piling on each other and then finally the brain gets covered with these plaques. Theses plaques lead to the Alzheimer's disease. There are various stages of this disease, like the initial loss of intelligence. The patient loses the ability for abstract thinking, judgment, and solving of problems.
Next it progresses to Memory impairment, where events of recent happening are forgotten.
Next it progresses to the changes in personality and also in emotional outlook. All these are the late changes in the progress of the disease.
The Alzheimer's disease is not a simple process. It involves many complex factors like multiple genetic defects or mutations in the genes. These mutations can be either hereditary and passed on from generation to generation. Or it may be acquired through increased susceptibility, which in turn may be due to various other factors.
The genomics or the study of the genetic progress of the disease has revealed that the Alzheimer's disease is caused due to the aging process. The aging process either accelerates the damage of the brain cells or when the person is exposed to deleterious environmental processes. The intake of certain drugs can also cause the harmful effect.
The multiple defects in the genes are at the following mutational loci (APP, PS1, TAU, PS2) and many other different susceptibility loci (APOE, AACT, A2M, TNF, BACE, BCHE, NOS3, GSK3B)
All these loci are spread across the human genome and they all meet together to effect the deleterious changes. The combined effects of these loci lead to untimely and premature death of the neurons. The neurons are the brain cells and thus it leads to death of the brain cells. This is the mechanism of loss of function of these cells and a resultant psychiatric disease.
The damage to the neurons are in various forms like aberrations in the protein content of the mitochondria, formation of protofibrils, altered function or dysfunction of the ubiquity-proteasome system, injury to the mitochondria, piling up of folded proteins, reactions which not only excite the system but also are toxic, stress etc.
Showing posts with label Alzheimer's Disease Causes. Show all posts
Showing posts with label Alzheimer's Disease Causes. Show all posts
Monday, June 23, 2014
Alzheimer's Disease Cure
Alzheimer's Disease Cure
Currently, there have been major scientific breakthroughs that give promise to preventing and controlling Alzheimer's disease, and perhaps eventually there will be an Alzheimer's disease cure in the future.
Alzheimer's disease is a very complex neurological disorder that most doctors who treat this condition believe that a cocktail drug similar to what is used to treat patients with AIDS could be the answer to controlling this disease.
Many scientists involved in the field of research for the treatment of this disease are receiving funding from The Alzheimer's Disease Association and have also obtained resources from various private and philanthropic companies.
Currently, research experts ascertain that a new series of treatments can evolve in to helping prevent, slowing down, or even reversing the detrimental affects of Alzheimer's disorder.
The most recent discover in the search for the Alzheimer's disease cure and control of progression has been discovered by researchers in the UK. A group of research scientists from the University Of Welsh School Of Pharmacy just finished up a study that shows how the disease process can be slowed down by the use of a small protein called Amyloid.
Amyloid is thought to be the same protein that is responsible for the disease, and could very well be the answer to controlling or slowing down the disease process of the disorder.
Researchers from UCLA have created a new brain imaging molecule that can reveal early detection of the disease by mapping out the tangles that cause the onset of cognitive interruptions and disturbances that are found in patients with Alzheimer's.
This discovery can lead to an early diagnosis of the disorder and can help in preventing, slowing down, or creating an Alzheimer's disease cure in the near future.
The drug Alzhemed has just recently been developed by a Quebec- based company that has proven to help slow down the progression of Alzheimer's and other dementia disorders. A trial of the drug will be administered within the beginning of next year.
The primary focus that researchers are working towards is to prevent Alzheimer's disease from slowly destroying neurological functioning within patients suffering from this disorder.
Today there are over twelve million people affected by the degenerating affects of Alzheimer's disease with an estimated cost of over a hundred billion dollars a year for treatment.
The research for finding an Alzheimer's disease cure has remained ongoing and is looking very promising in the future. Some of the strategies being looked into include how to maintain a healthy lifestyle as a key in preventing the onset of the disease.
Currently, there have been major scientific breakthroughs that give promise to preventing and controlling Alzheimer's disease, and perhaps eventually there will be an Alzheimer's disease cure in the future.
Alzheimer's disease is a very complex neurological disorder that most doctors who treat this condition believe that a cocktail drug similar to what is used to treat patients with AIDS could be the answer to controlling this disease.
Many scientists involved in the field of research for the treatment of this disease are receiving funding from The Alzheimer's Disease Association and have also obtained resources from various private and philanthropic companies.
Currently, research experts ascertain that a new series of treatments can evolve in to helping prevent, slowing down, or even reversing the detrimental affects of Alzheimer's disorder.
The most recent discover in the search for the Alzheimer's disease cure and control of progression has been discovered by researchers in the UK. A group of research scientists from the University Of Welsh School Of Pharmacy just finished up a study that shows how the disease process can be slowed down by the use of a small protein called Amyloid.
Amyloid is thought to be the same protein that is responsible for the disease, and could very well be the answer to controlling or slowing down the disease process of the disorder.
Researchers from UCLA have created a new brain imaging molecule that can reveal early detection of the disease by mapping out the tangles that cause the onset of cognitive interruptions and disturbances that are found in patients with Alzheimer's.
This discovery can lead to an early diagnosis of the disorder and can help in preventing, slowing down, or creating an Alzheimer's disease cure in the near future.
The drug Alzhemed has just recently been developed by a Quebec- based company that has proven to help slow down the progression of Alzheimer's and other dementia disorders. A trial of the drug will be administered within the beginning of next year.
The primary focus that researchers are working towards is to prevent Alzheimer's disease from slowly destroying neurological functioning within patients suffering from this disorder.
Today there are over twelve million people affected by the degenerating affects of Alzheimer's disease with an estimated cost of over a hundred billion dollars a year for treatment.
The research for finding an Alzheimer's disease cure has remained ongoing and is looking very promising in the future. Some of the strategies being looked into include how to maintain a healthy lifestyle as a key in preventing the onset of the disease.
Alzheimer's Disease Cause
Alzheimer's Disease Cause
As much as there has not yet been any known cure for the disease, it is widely researched about and the research has so far led to the establishment of some of the main causes of the condition. Among the most possible courses of the condition are age in complement with the hereditary traits. If the family lineage has a determinate gene that significantly causes this type of disease, then it is almost certain that you will degenerate into an Alzheimer's disease patient with age.
A natural factor I age which plays a major role in the development of the disease. It is only natural that any body registers certain decline in functionality with age. As much as this is true about any body if not all animals, the case of Alzheimer's disease is however quite different. The rate at which a victim's memory degenerates as they age when they have the disease is quite alarming as compared to the usual memory related problems that affect all people in old age.
Another serious cause of Alzheimer's disease is the personal lifestyle of individuals. For people without genetic links to the disease, lifestyle may enhance their chances of developing the disorder. It has been verified that serious head injuries will most likely lead to the possibility of developing the disease as they continue to age. If you have been involved in an accident that resulted in serious head injuries, the chances are quite high that you may develop the Alzheimer's disease. This discovery should draw our attention to the risk that professional boxers are exposed to in the line of their daily duties.
When thinking about lifestyles that may influence the development of the disease, it is important to note that alcohol consumption and narcotics are sure products that can enhance an individual's chances of developing the disease in later years. This is because these are products that have a direct impact on the individual's thinking pattern even in the absence of old age or dementia. The final factor that has been confirmed to have an influence in the development of the disease is the heart diseases. It is clinically proven that the heart's strength and health plays a big influential role in the development of the disease. People with heart related complications have higher chances of developing the disease as compared to their strong hearted counterparts. This should give us the wake up call to try and take part in regular exercise and to maintain physical fitness as this automatically leads to good mental health
As much as there has not yet been any known cure for the disease, it is widely researched about and the research has so far led to the establishment of some of the main causes of the condition. Among the most possible courses of the condition are age in complement with the hereditary traits. If the family lineage has a determinate gene that significantly causes this type of disease, then it is almost certain that you will degenerate into an Alzheimer's disease patient with age.
A natural factor I age which plays a major role in the development of the disease. It is only natural that any body registers certain decline in functionality with age. As much as this is true about any body if not all animals, the case of Alzheimer's disease is however quite different. The rate at which a victim's memory degenerates as they age when they have the disease is quite alarming as compared to the usual memory related problems that affect all people in old age.
Another serious cause of Alzheimer's disease is the personal lifestyle of individuals. For people without genetic links to the disease, lifestyle may enhance their chances of developing the disorder. It has been verified that serious head injuries will most likely lead to the possibility of developing the disease as they continue to age. If you have been involved in an accident that resulted in serious head injuries, the chances are quite high that you may develop the Alzheimer's disease. This discovery should draw our attention to the risk that professional boxers are exposed to in the line of their daily duties.
When thinking about lifestyles that may influence the development of the disease, it is important to note that alcohol consumption and narcotics are sure products that can enhance an individual's chances of developing the disease in later years. This is because these are products that have a direct impact on the individual's thinking pattern even in the absence of old age or dementia. The final factor that has been confirmed to have an influence in the development of the disease is the heart diseases. It is clinically proven that the heart's strength and health plays a big influential role in the development of the disease. People with heart related complications have higher chances of developing the disease as compared to their strong hearted counterparts. This should give us the wake up call to try and take part in regular exercise and to maintain physical fitness as this automatically leads to good mental health
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