Osteogenesis imperfecta. A group of genetic diseases of the
bones. Divided into four types all result in brittle and frail bones.
Multiple broken bones are common. Other features include deafness,
white of the eyes appear bluish, kyphosis, kyphoscoliosis, tooth
abnormalities, chest deformities and short stature. There is no
specific treatment. Genetic counseling is important for families with
the disease.
Brittle bone disease is caused by a mutation in the gene that
controls the production of an important substance found in bone called
collagen. This collagen material normally forms into a long rope that
is composed of three tightly woven strands and is almost as strong as
steel wire.
In osteogenesis imperfecta, however, the bone cells produce a
defective form of collagen which is unable to form the triple-stranded
rope. This results in a loose and very weak bone structure that does
not contain enough calcium and that breaks easily.
Osteogenesis imperfecta is characterized by the following:
- Frequent fractures
- Progressive limb deformities
- Loss of independent mobility
- Chronic bone pain
- Short stature
There is no cure for OI. Up until now, various treatments aimed at
increasing bone mass and reducing the risk of fractures had been tried,
but without significant success.
The following combinations are those recommended for people with brittle bone disease.
Vitamins : C
Minerals : Calcium, Magnesium, Zinc, Manganese, Silica
Food Supplements : Cod Liver Oil (for Vitamin D), Nutritional Yeast
The
nutrients mentioned above reflect the major nutritional supplements
that may help the condition. Please do remember however that
nutritional supplementation is an adjunct to medical treatment and in
no way replaces medical treatment.
