Medical Uses For Inosine
Inosine is not an amino acid but is classified as a nucleoside,
one of the basic compounds comprising cells. It is a precursor to
adenosine, an important energy molecule, and plays many supportive
roles in the body, including releasing insulin, facilitating the use of
carbohydrate by the heart, and, potentially, participating in oxygen
metabolism and protein synthesis.
It is associated with the development of purines, nonprotein
nitrogen compounds that have important roles in energy metabolism. It
has been suggested that inosine may improve ATP (Adenosine
Tri-Phosphate) production in the muscle and thus be of value to
strength athletes. It is also thought to enhance oxygen delivery to the
muscles which would benefit endurance athletes.
Inosine is a metabolic activator. It has been used for pre-heavy
training by "world class" power-lifters, Soviet and Eastern Block
strength athletes to increase oxygen-carrying capacity and promote
levels of ATP a high energy compound that helps muscle contraction.
Inosine increases the body's natural ability to handle strenuous
exercise, workouts, intense training programs, and competitive events.
Inosine belongs to a chemical family called purine nucleotides, the
structural units of your body's RNA (ribonucleic acid) and DNA
(deoxyribonucleic acid). Inosine easily penetrates the cell walls of
both your cardiac and skeletal muscles there inosine helps the
generation of ATP. Inosine boosts the production of ATP thus improving
respiration and oxygen transport.
Extracellular purines, including adenosine and ATP, are potent
endogenous immunomodulatory molecules. Inosine, a degradation product
of these purines, can reach high concentrations in the extracellular
space under conditions associated with cellular metabolic stress such
as inflammation or ischemia. In the present study, we investigated
whether extracellular inosine can affect inflammatory/immune
processes... Inosine suppressed proinflammatory cytokine production and
mortality in a mouse endotoxemic model. Taken together, inosine has
multiple anti-inflammatory effects. These findings, coupled with the
fact that inosine has very low toxicity, suggest that this agent may be
useful in the treatment of
inflammatory/ischemic diseases.
Inosine is not an amino acid but is classified as a nucleoside,
one of the basic compounds comprising cells. It is a precursor to
adenosine, an important energy molecule, and plays many supportive
roles in the body, including releasing insulin, facilitating the use of
carbohydrate by the heart, and, potentially, participating in oxygen
metabolism and protein synthesis.
It is associated with the development of purines, nonprotein
nitrogen compounds that have important roles in energy metabolism. It
has been suggested that inosine may improve ATP (Adenosine
Tri-Phosphate) production in the muscle and thus be of value to
strength athletes. It is also thought to enhance oxygen delivery to the
muscles which would benefit endurance athletes.
Inosine is a metabolic activator. It has been used for pre-heavy
training by "world class" power-lifters, Soviet and Eastern Block
strength athletes to increase oxygen-carrying capacity and promote
levels of ATP a high energy compound that helps muscle contraction.
Inosine increases the body's natural ability to handle strenuous
exercise, workouts, intense training programs, and competitive events.
Inosine belongs to a chemical family called purine nucleotides, the
structural units of your body's RNA (ribonucleic acid) and DNA
(deoxyribonucleic acid). Inosine easily penetrates the cell walls of
both your cardiac and skeletal muscles there inosine helps the
generation of ATP. Inosine boosts the production of ATP thus improving
respiration and oxygen transport.
Extracellular purines, including adenosine and ATP, are potent
endogenous immunomodulatory molecules. Inosine, a degradation product
of these purines, can reach high concentrations in the extracellular
space under conditions associated with cellular metabolic stress such
as inflammation or ischemia. In the present study, we investigated
whether extracellular inosine can affect inflammatory/immune
processes... Inosine suppressed proinflammatory cytokine production and
mortality in a mouse endotoxemic model. Taken together, inosine has
multiple anti-inflammatory effects. These findings, coupled with the
fact that inosine has very low toxicity, suggest that this agent may be
useful in the treatment of
inflammatory/ischemic diseases.
- Gy?rgy Hask?, Et al. Inosine Inhibits Inflammatory Cytokine
Production by a Posttranscriptional Mechanism and Protects Against
Endotoxin-Induced Shock. The Journal of Immunology, 2000, 164:
1013-1019.
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