The Importance Of Isoleucine
L-Isoleucine is a neutral, genetically coded amino acid. It is
essential in human nutrition. Isoleucine is found in especially high
amounts in meats, fish, cheese, most seeds and nuts, eggs, chickens and
lentils. In the human body Isoleucine is concentrated in the muscle
tissues. Isoleucine is necessary for hemoglobin formation and in
stabilizing and regulating blood sugar and energy levels. A deficiency
of isoleucine can produce symptoms similar to those of hypoglycemia.
It is one of several essential amino acids needed in the diet; human
beings cannot synthesize it from simpler metabolites. Young adults need
about 20 mg of this amino acid per day per kg (or about 8 mg per lb) of
body weight. Isoleucine can be degraded into simpler compounds by the
enzymes of the body.
It is used in the body to produce certain biochemical compounds that
help in energy production and has been found experimentally to reduce
twitching and tremors in animals. The branched-chain amino acids
(BCAA)?isoleucine, leucine, and valine?have been used as supplements
for body (muscle) building.
Both aerobic exercise and strength training increase protein
requirements although they do so for different reasons. During aerobic
exercise, AAs can be used for energy production (especially the
branch-chain AA's, leucine, isoleucine, and valine) and may provide up
to 10% of the total energy produced during long-duration activity.
Chronic renal failure (CRF) patients on hemodialysis have low plasma
level of the branched chain amino acids (BCAA) leucine, isoleucine, and
valine. The abnormalities in the plasma amino acid pool can be
corrected with appropriate high-protein supplements. The present study
was designed to evaluate the effect of a balanced protein nutritional
supplement on the plasma level of BCAA...The plasma BCAA levels were
maintained high until the sixth month from the beginning of trial and
even a month after withdrawal of the supplement. The results obtained
allow us to recommend inclusion of protein supplements with balanced
amino acid content in the diet of these patients.
L-Isoleucine is a neutral, genetically coded amino acid. It is
essential in human nutrition. Isoleucine is found in especially high
amounts in meats, fish, cheese, most seeds and nuts, eggs, chickens and
lentils. In the human body Isoleucine is concentrated in the muscle
tissues. Isoleucine is necessary for hemoglobin formation and in
stabilizing and regulating blood sugar and energy levels. A deficiency
of isoleucine can produce symptoms similar to those of hypoglycemia.
It is one of several essential amino acids needed in the diet; human
beings cannot synthesize it from simpler metabolites. Young adults need
about 20 mg of this amino acid per day per kg (or about 8 mg per lb) of
body weight. Isoleucine can be degraded into simpler compounds by the
enzymes of the body.
It is used in the body to produce certain biochemical compounds that
help in energy production and has been found experimentally to reduce
twitching and tremors in animals. The branched-chain amino acids
(BCAA)?isoleucine, leucine, and valine?have been used as supplements
for body (muscle) building.
Both aerobic exercise and strength training increase protein
requirements although they do so for different reasons. During aerobic
exercise, AAs can be used for energy production (especially the
branch-chain AA's, leucine, isoleucine, and valine) and may provide up
to 10% of the total energy produced during long-duration activity.
Chronic renal failure (CRF) patients on hemodialysis have low plasma
level of the branched chain amino acids (BCAA) leucine, isoleucine, and
valine. The abnormalities in the plasma amino acid pool can be
corrected with appropriate high-protein supplements. The present study
was designed to evaluate the effect of a balanced protein nutritional
supplement on the plasma level of BCAA...The plasma BCAA levels were
maintained high until the sixth month from the beginning of trial and
even a month after withdrawal of the supplement. The results obtained
allow us to recommend inclusion of protein supplements with balanced
amino acid content in the diet of these patients.
- Peter Lemon. Is increased dietary protein necessary or beneficial
for individuals with a physically active lifestyle. Nutr Rev (1996) 54:
S169-S175. - Vuzelov E, Krivoshiev S, Ribarova F, Boyadjiev N. Plasma levels of
branched chain amino acids in patients on regular hemodialysis before
and after including a high-protein supplement in their diet. Folia Med
(Plovdiv) 1999;41(4):19-22
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